Professor Yuval Garini
Understanding the principles of living systems
I am interested to explore the mechanisms of (a few) living systems. Living systems eveolved for billions of years. They are extremely complex, involve redundent mechanisms that ensure proper functioning, involve multi-scales in space and time, and form highly complex dynamic networks.
A major focus theme in my research is the genome organization in the nucleus of eukaryotic cells. It is a fascinating system that requires to exploit all possible experimental capabilities, and further develope new methods.
It also requires to adopt and develop theoretical models in order to expose the principles of the systems. Live-cell imaging is a central motif in my lab, and it is naturally based on optical microscopy. We also heavily use single-molecule methods, nanotechnology and other means.
Each discovery is an award. Not only we gain a deeper understanding, but it also reflects on the ability to use the discovery for improving human health, fight cancer and develope better diagnostics tools.
Current and previous research Projects
DNA-based nano structures such as DNA Origami and its usage for biophysical purposes and for live-cell methods such as RNA expression level analysis in vivo.
Organization of the genome in the nucleus and its alteration through diseases and cancer. Studies include advanced dynamic methods in live cells and modeling.
DNA-protein single molecule interaction detection by a unique tethered particle motion method that uses metal nano-beads.
Development of advanced live-cell measurements for exploring the dynamic properties of proteins, DNA and organelles in live cells.
Development of spectral imaging systems and applications for cytogenetics and pathology, including the development of spectral imaging systems and the method called Spectral Karyotyping that is broadly used all around the world for diagnostics and research.
2020 – Full professor, Biomedical Engineering, Technion
2019 – Committees head, Israel Council for Higher Education
2017 – Leader of advanced-learning initiative programs
2017 – Founder, Nanoscience-Art museum, Bar Ilan University
2015 – Full professor, Physics Department, Bar-Ilan University
2016 – Committees member, Israel Academy of Sciences
2013 – 2018 Head, Bar Ilan Institute of Nanotechnology
2007 – 2015 Senior & Associate Prof., Physics Department, Bar-Ilan University, Ramat Gan, Israel.
2002 – 2006 Assistant Professor, Delft University, Faculty of Applied Sciences, The Netherlands
1994 – 2001 Applied Spectral Imaging, Israel R&D director
Professional & Awards
2018 Chair NANO.IL conference, Jerusalem, Israel
2016 – Leon and Maria Taubenblatt Prize for Excellence in Medical Research 2016.
2007 – Board member Israeli Live Imaging Forum (ILIF)
2009 – 2016 Council member & treasurer, Israeli Physics Society
2009 Excellent Lecturer award, Bar Ilan University 2009
Editorial board, various journals
Member: American Association of Biophysics, SPIE & more
1990-1994 Ph.D., Physics, Technion – Israel institute of Technology, Haifa, Israel.
1987-1990 Master, Physics, Technion – Israel institute of Technology, Haifa, Israel.
1984-1987 B.Sc., Physics, Technion – Israel institute of Technology, Haifa, Israel.